Simultaneous HPLC determination of markers of metabolic activity of CYP1A2 and CYP2C6

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Authors	JUŘICA Jan TOMANDL Josef ZAHRADNÍKOVÁ Lucia ZENDULKA Ondřej HADAŠOVÁ Eva
Year of publication	2006
Type	Article in Proceedings
Conference	Book of abstracts, Central/Eastern European CINP Regional meeting
MU Faculty or unit	Faculty of Medicine
Citation
Field	Pharmacology and pharmaceutical chemistry
Keywords	determination; cytochrome; CYP2C6; CYP1A2
Description	The presented method allows to determine concentration of both markers of metabolic activity of CYP1A and CYP2C (phenacetine and tolbutamide) and their metabolites paracetamol and 4-hydroxytolbutamide in rat liver perfusate, respectively. This method is suitable for modeling and description of possible pharmacological interactions on isoforms CYP1A2 and CYP2C6 in rat.
Related projects:	The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions. Capillary electrophoresis as a tool for the drug-metabolism studies Integrované bioanalytické technologie pro mikroanalýzy a diagnostiku s využitím LIF a hmotnostní spektrometrie