Detection of chromosomal aberrations in multiple myeloma

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Authors

HÁJEK Roman KUGLÍK Petr NĚMEC Pavel ZAORALOVÁ Romana GREŠLIKOVÁ Henrieta FILKOVÁ Hana KUPSKÁ Renata PETROVIČOVÁ Gabriela

Year of publication 2006
Type Workshop
MU Faculty or unit

Faculty of Informatics

Citation
Description The purpose of the workshop was the teaching of technique of light chain-specific immunofluorescent staining of clonal plasma cells and FISH analyses in multiple myeloma (MM). Immunofluorescent labelling of malignant plasma cells is suitable approach for the diagnosis of chromosomal abnormalities in patients with MM. This method allows selection of monotypic plasma cells by monoclonal antibody fluorescence (anti-kappa or anti- lambda) and detection of chromosomal abnormalities by interphase FISH (cIg FISH).
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