The interaction of MMP-9 and IL-18 gene promoter polymorphisms in children with gingivitis

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Authors

VOKURKA Jan MORAVCOVÁ Pavla KLAPUŠOVÁ Lucie KUKLETOVÁ Martina IZAKOVIČOVÁ HOLLÁ Lydie

Year of publication 2006
Type Article in Proceedings
Conference Book of Abstracts, 5th Meeting of the European Mucosal Immunology Group
MU Faculty or unit

Faculty of Medicine

Citation
Field ORL, ophthalmology, stomatology
Keywords gene; polymorphism; IL-18; MMP-9; gingivitis
Description Matrix metalloproteinase 9 (MMP-9) as a proteolytic enzyme plays an important role in tissue remodeling and repair. Interleukin 18 (IL-18) as a member of IL-1 proinflammatory family participates in regulation of expression of MMP-9. The aim of our study was to determine differences between Czech children with and without gingivitis in relation to the distribution of MMP-9 and IL-18 variants.
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