Serum matrix metalloproteinase (MMP-2) and its tissue inhibitor (TIMP-1) in relation to pro- and anti-fibrotic factors in patients with heart failure
| Authors | |
|---|---|
| Year of publication | 2006 |
| Type | Article in Proceedings |
| Conference | Proceedings from XX. Biochemický zjazd |
| MU Faculty or unit | |
| Citation | |
| Field | Biochemistry |
| Keywords | metalloproteinase - tissue inhibitor - fibrotic factors - heart failure |
| Description | Matrix metalloproteinase MMP-2 and its endogenous inhibitor TIMP-1 are associated with extracellular matrix remodeling, which may lead to interstitial fibrosis and thus contribute to heart failure. Besides, pro- and anti-fibrotic factors such as endothelin-1 and nitric oxide, respectively, regulate fibrosis by modulating collagen synthesis and also MMP/TIMP activity. Nowadays, there is thought that progressive remodeling accompanied with changes in the extracellular matrix may lead to severe heart failure. The aim of this study was to find a relationship between MMP-2/TIMP-1 and other above mentioned parameters in patients with heart failure. |
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