Serum matrix metalloproteinase (MMP-2) and its tissue inhibitor (TIMP-1) in relation to pro- and anti-fibrotic factors in patients with heart failure

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Authors

TOMANDL Josef PAULOVÁ Hana ŠPINAROVÁ Lenka TÁBORSKÁ Eva ŠPINAR Jindřich

Year of publication 2006
Type Article in Proceedings
Conference Proceedings from XX. Biochemický zjazd
MU Faculty or unit

Faculty of Medicine

Citation
Field Biochemistry
Keywords metalloproteinase - tissue inhibitor - fibrotic factors - heart failure
Description Matrix metalloproteinase MMP-2 and its endogenous inhibitor TIMP-1 are associated with extracellular matrix remodeling, which may lead to interstitial fibrosis and thus contribute to heart failure. Besides, pro- and anti-fibrotic factors such as endothelin-1 and nitric oxide, respectively, regulate fibrosis by modulating collagen synthesis and also MMP/TIMP activity. Nowadays, there is thought that progressive remodeling accompanied with changes in the extracellular matrix may lead to severe heart failure. The aim of this study was to find a relationship between MMP-2/TIMP-1 and other above mentioned parameters in patients with heart failure.
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