Význam CYP2D6 v terapii SSRI

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Title in English The role CYP2D6 in the treatment with SSRIs
Authors

PILAŘOVÁ Lucie ŽOURKOVÁ Alexandra

Year of publication 2006
Type Article in Periodical
Magazine / Source Česká a Slovenská Psychiatrie
MU Faculty or unit

Faculty of Medicine

Citation
Field Psychiatry, sexuology
Keywords SSRIs;Cytochrome P4502D6; metabolic phenotype; extensive metaboliser; poor metaboliser
Description SSRIs are potent inhibitors of the CYP2D6 activity and that fact may lead to the chahges of metabolic phenotype which may not correspond to metabolic genotype. The result is a great variability in tolerance and efficaccy of SSRIs therapy.
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