Význam CYP2D6 v terapii SSRI

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Title in English	The role CYP2D6 in the treatment with SSRIs
Authors	PILAŘOVÁ Lucie ŽOURKOVÁ Alexandra
Year of publication	2006
Type	Article in Periodical
Magazine / Source	Česká a Slovenská Psychiatrie
MU Faculty or unit	Faculty of Medicine
Citation
Field	Psychiatry, sexuology
Keywords	SSRIs;Cytochrome P4502D6; metabolic phenotype; extensive metaboliser; poor metaboliser
Description	SSRIs are potent inhibitors of the CYP2D6 activity and that fact may lead to the chahges of metabolic phenotype which may not correspond to metabolic genotype. The result is a great variability in tolerance and efficaccy of SSRIs therapy.
Related projects:	The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.