The Effect Of Perphenazine On Transient Outward Potassium Current In Rat Ventricular Myocytes
| Authors | |
|---|---|
| Year of publication | 2006 |
| Type | Article in Proceedings |
| Conference | Analysis of Biomedical Signals and Images |
| MU Faculty or unit | |
| Citation | |
| Field | Physiology |
| Keywords | rat ventricular myocyte; transient outward current; perphenazine |
| Description | The aim of this study was to explore the effect of a phenothiazine neuroleptic drug perphenazine on transient outward potassium current Ito in rat ventricular myocytes. Perphenazine reversibly decreased the amplitude and accelerated the apparent inactivation of Ito in a concentration-dependent manner with EC50 = 26.4 +/- 3.5 umol/l and Hill coefficient n = 0.84 +/- 0.10 (evaluated from changes of time integral of Ito). Time course of Ito-inactivation was well fitted by a double exponential function; the fast time constant tf was significantly decreased under the effect of perphenazine and its concentration dependence was comparable with the concentration dependence of Ito-block represented by time integrals (EC50 = 26.8 +/- 8.2 umol/l, n = 0.88 +/- 0.28). It is suggested that perphenazine-induced block via open channel is very likely involved in the mechanism of drug-channel interaction. |
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