The Effect Of Perphenazine On Transient Outward Potassium Current In Rat Ventricular Myocytes

Investor logo

Warning

This publication doesn't include Faculty of Sports Studies. It includes Faculty of Medicine. Official publication website can be found on muni.cz.
Authors

BÉBAROVÁ Markéta MATEJOVIČ Peter PÁSEK Michal RAČKAUSKAS G. ŠIMURDOVÁ Milena ŠIMURDA Jiří NOVÁKOVÁ Marie

Year of publication 2006
Type Article in Proceedings
Conference Analysis of Biomedical Signals and Images
MU Faculty or unit

Faculty of Medicine

Citation
Field Physiology
Keywords rat ventricular myocyte; transient outward current; perphenazine
Description The aim of this study was to explore the effect of a phenothiazine neuroleptic drug perphenazine on transient outward potassium current Ito in rat ventricular myocytes. Perphenazine reversibly decreased the amplitude and accelerated the apparent inactivation of Ito in a concentration-dependent manner with EC50 = 26.4 +/- 3.5 umol/l and Hill coefficient n = 0.84 +/- 0.10 (evaluated from changes of time integral of Ito). Time course of Ito-inactivation was well fitted by a double exponential function; the fast time constant tf was significantly decreased under the effect of perphenazine and its concentration dependence was comparable with the concentration dependence of Ito-block represented by time integrals (EC50 = 26.8 +/- 8.2 umol/l, n = 0.88 +/- 0.28). It is suggested that perphenazine-induced block via open channel is very likely involved in the mechanism of drug-channel interaction.
Related projects:

You are running an old browser version. We recommend updating your browser to its latest version.

More info