Relationship between circulating levels of soluble RAGE (sRAGE) and genetic variability in the AGER gene in subjects with diabetic nephropathy

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Authors	KAŇKOVÁ Kateřina KALOUSOVÁ Marta HERTLOVÁ Miluše KRUSOVÁ Darja ZIMA Tomáš
Year of publication	2006
Type	Conference abstract
MU Faculty or unit	Faculty of Informatics
Citation
Description	RAGE2 haplotype was previously identified as a genetic risk factor for the development and early onset of diabetic nephropathy. Curent study showed that (i) sRAGE significantly differed among subjects bearing variable number of RAGE2 haplotype copies, (ii) was significantly higher in subjects with nephropathy than normoalbuminuric patients and (iii) positively correlated with severity of nephropathy, S-urea, S-creatinine and negatively with glomerular filtration rate (GFR). GFR seems to be principal determinant of the AGE and sRAGE levels.
Related projects:	Functional analysis of the RAGE gene susceptibility haplotype and its role in the hyperglycemia-driven pathology