A keratinocyte-produced inhibitor is differentially active against two isoforms of MSF

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Authors	JONES Sarah FLORENCE Margaret ELLIS Ian KAY Richard COX Jacqueline KAŇKOVÁ Kateřina SCHOR Seth SCHOR Ana
Year of publication	2006
Type	Conference abstract
MU Faculty or unit	Faculty of Medicine
Citation	JONES, Sarah, Margaret FLORENCE, Ian ELLIS, Richard KAY, Jacqueline COX, Kateřina KAŇKOVÁ, Seth SCHOR and Ana SCHOR. A keratinocyte-produced inhibitor is differentially active against two isoforms of MSF. In British Microcirculation Society Meeting 2006. 2006.
Description	MSF is a truncated (70kDa) isoform of fibronecting displaying number of potent biactivities mediated by IGD-amino acid motif. Two MSF isoforms, differing in terms of 15 amino acid deletion in a module II-1, have been identified. While IGD-mediated bioactivities od both isoforms are identical, deleted isoform (MSF-aa) is not inhibited by recently characterised inhibitor produced by normal keratinocytes. Furthermore, various cancer cell lines produce MSF activity which is not inhibited or partly inhibited by MSF inhibitor.
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