Association study of promoter polymorphisms within NOS3 gene with allergic diseases
| Authors | |
|---|---|
| Year of publication | 2006 |
| Type | Article in Periodical |
| Magazine / Source | International Archives of Allegy and Immunology |
| MU Faculty or unit | |
| Citation | |
| Field | Immunology |
| Keywords | asthma; gender difference; nitric oxide; polymorphism; NOS3; eNOS; endothelial nitric oxide synthase |
| Description | Nitric oxide (NO) is an important mediator of physiologic and pathologic processes in the airways. On this basis, we hypothesised that polymorphisms in the NOS3 gene could be associated with the disease process.Two promoter variants (-786C/T and -691C/T) were examined in a Caucasian Czech population of allergic patients [n=671, with a subgroup of asthmatics (n=305)] and healthy controls (n=334) using PCR-RFLP analyses. NOS3 -786C/T and -691C/T were not associated with allergic diseases or asthma. However, the 786 variant was significantly associated with asthma in men (p < 0.01, Pcorr < 0.05) but not in women. NOS3 -691C/T was found to be in strong linkage disequilibrium with -786C/T, and the distribution of combined genotypes was marginally different between the asthmatic and control men. Our results suggest that NOS3 gene variants may be one of the factors that participate in the pathogenesis of asthma in men. |
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