Physiological role of transverse-axial tubular system in cardiac ventricular myocytes: a simulation study
| Authors | |
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| Year of publication | 2005 |
| Type | Article in Proceedings |
| Conference | Computers in cardiology 2005 |
| MU Faculty or unit | |
| Citation | |
| Field | Physiology |
| Keywords | cardiac cell; tubular system; quantitative modelling |
| Description | Experimental data related to the transverse - axial tubular system of guinea pig and rat ventricular myocytes were incorporated into quantitative models of their electrical activity. The results of simulations suggest that activity-dependent depletion of Ca within the tubular lumen decreases the intracellular Ca-load and intracellular Ca-transients in both species. However, considerable species differences in the magnitude of the depletion, its frequency dependence and the resulting effect on cellular activity were observed. |
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