A novel quantitative description of electrophysiological processes in guinea pig ventricular cardiomyocytes

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Authors

PÁSEK Michal CHRISTÉ Georges ŠIMURDA Jiří

Year of publication 2005
Type Article in Proceedings
Conference Engineering Mechanics 2005
MU Faculty or unit

Faculty of Medicine

Citation
Field Physiology
Keywords cardiac cell; tubular system; quantitative modelling
Description A novel quantitative model of a guinea-pig ventricular myocyte has been designed with transverse-axial tubular system (TATS) included. This model displays long-term stability and closely reproduces experimental activity-related changes in action potentials and ionic concentrations inside the cell and in the lumen of the TATS. It allows exploration of species-specific functional consequences of the presence of the TATS in a biophysically realistic way.
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