Using of electrochemical methods for studying of metallothionein content in the human blood serum of a patient poisoned by lead and treated by platinum.

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Authors	PETRLOVÁ Jitka BLAŠTÍK Ondřej PRŮŠA Richard KUKAČKA Martin POTĚŠIL David MIKELOVÁ Radka ADAM Vojtěch ZEHNÁLEK Josef KIZEK René
Year of publication	2005
Type	Article in Periodical
Magazine / Source	Biomedical Papers
MU Faculty or unit	Faculty of Science
Citation
Field	Electrochemistry
Keywords	Metallothionein; Brdicka reaction; Peak H; Catalytic hydrogen reaction; Cancer; Lead; Differential pulse voltammetry; Adsorptive stripping voltammetry
Description	Metallothioneins belong to the group of intracellular, high molecular and cysteine-rich proteins whose content increase with increasing concentration of a heavy metal. Here we applied the adsorptive transfer stripping differential pulse voltammetry Brdicka reaction for the determination of metallothionein in human blood serum of patient poisoned by lead and/or treated by platinum. The increased metallothionein concentrations in both cases were observed.
Related projects:	Interactions among the chemicals, environment and biological systems and their consequences on the global, regional and local scales (INCHEMBIOL)