Action potential voltage clamp analysis of rate-dependent changes of action potential in rat ventricular myocytes

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Authors	BÉBAROVÁ Markéta MATEJOVIČ Peter PÁSEK Michal ŠIMURDOVÁ Milena ŠIMURDA Jiří
Year of publication	2005
Type	Conference abstract
MU Faculty or unit	Faculty of Medicine
Citation
Description	The main determinants of rate-dependent of action potential duration in rat ventricular myocytes are variations of the L-type calcium current ICa-L (gradual increase caused by modulatory effect of the Ca2+ transient) and the transient outward current Ito (decrease due to cumulative inactivation). These contemporary variations of ICa-L and Ito supported each other in the rate-dependent modulation of action potential prolongation. Under our experimental conditions, participation of other currents was negligible.
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