Interactions of Behavioural Sensitizing Processes to Methamphetamine and Cannabinoids (comparative study in laboratory rodents)
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| Year of publication | 2005 |
| Type | Monograph |
| MU Faculty or unit | |
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| Description | The outcomes of experiments investigating a development of sensitization to methamphetamine effect on mouse ambulatory activity in the open field test are threefold. First, they confirmed a well-known fact that repeated administration of methamphetamine produces behavioural sensitization to its stimulatory effects. Secondly, cannabinoid CB1 receptor stimulation by agonist methanandamide cross-sensitized to methamphetamine, while blocking of the CB1 receptor with antagonist AM 251 during the sensitizing phase with methamphetamine suppressed this phenomenon in the same animal model. Finally, cannabinoid CB2 receptor stimulation by agonist JWH 015 did not cause cross-sensitization to methamphetamine in the present study. In final evaluation, a similar investigation in rats brought very resembling results described above in mice. However, there were registered at least some interspecies differences in the rat susceptibility to development of sensitization to methamphetamine effects. Comparing to mice it was more demanding to titrate a dose of methamphetamine producing behavioural sensitization to ambulatory rat activity in the open field test, however unlike in mice there was registered an alternative behavioural change after repeated methamphetamine treatment instead the occurrence of stereotypic behaviour (nose rubbing). In the model of agonistic behaviour in mice there was found after repeated treatment a behavioural sensitization to inhibitory methamphetamine effects on aggressive behaviour. The pre-treatment with cannabinoid CB1 and CB2 receptor agonist caused and did not cause, respectively, a cross-sensitization to methamphetamine antiaggressive effects, whereas a combined pre-treatment with methamphetamine+cannabinoid CB1 receptor antagonits suppressed the development of sensitization to antiaggressive methamphetamine effects. |
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