Extracellular diffusion parameters during and after unilateral carotid occlusion in rat

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Authors

ŠLAIS Karel HOMOLA Aleš SYKOVÁ Eva

Year of publication 2005
Type Article in Proceedings
Conference Sborník abstrakt 5. konference České neurovědecké společnosti
MU Faculty or unit

Faculty of Medicine

Citation
Field Neurology, neurosurgery, neurosciences
Keywords diffusion; ischemia; carotid occlusion; stroke
Description Measurements of the ECS diffusion parameters in the brain have shown that a decreases and l increases during global cerebral ischemia, but there is a lack of information about the ECS parameters during hypoxia-ischemia and in the post-ischemic period after unilateral carotid occlusion. The observed post-ischemic increase in a and decrease in l suggest that extrasynaptic communication between neurons and glia is altered during the post-ischemic period. Moreover, the concentrations of neuroactive substances, metabolites and applied drugs may be altered and could play an important role in the recovery process from stroke.
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