The relationship between the carotid intima-media thickness, baroreflex sensitivity, variability in blood pressure and heart rate, and ejection fraction in normotensives and hypertensives
| Authors | |
|---|---|
| Year of publication | 2005 |
| Type | Article in Periodical |
| Magazine / Source | Scripta medica |
| MU Faculty or unit | |
| Citation | |
| Field | Physiology |
| Keywords | Carotid intima-media thickness; Baroreflex sensitivity; Heart rate variability; Blood pressure variability |
| Description | A complex analysis of relationship between carotid intima-media thickness (IMT) and baroreflex sensitivity was performed in normotensives and hypertensives with respect to the signs of tonic and reflex autonomic control of heart rate and blood pressure (BP).The hierarchical multiple regression analysis by means of the forward selection of regressors proved an additive positive effect of age and BMI on a development of IMT in normotensives, but the influence of mean BP was insignificant . The same analysis performed in hypertensives showed, that their thick IMT is not further influenced neither by age nor by BMI nor by mean BP. Taking all subjects together, the dependence of IMT on age and mean BP from 24-h recordings was shown. Correlation of IMT with BRS and BRSf confirmed the hypothesis that the thickened carotid wall has lower compliance and therefore baroreflex sensitivity is lower. IMT correlates with many indices, but the increase of IMT in healthy subjects is dependent on age and BMI. BP plays a role besides age in thickening of carotid wall during the development of hypertension. It is probable that therapy in hypertonics decreases only sympathetic activation, but decreased BRS which is a risk factor for sudden cardiac death after myocardial infarction is not influenced by therapy. |
| Related projects: |