Structures and mechanisms of glycosyltransferases

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Authors

BRETON Christelle ŠNAJDROVÁ Lenka JEANNEAU Charlotte KOČA Jaroslav IMBERTY Anne

Year of publication 2006
Type Article in Periodical
Magazine / Source Glycobiology
MU Faculty or unit

Faculty of Science

Citation
Web Database of three-dimensional structures of glycosyltransferases
Field Biochemistry
Keywords glycosyltransferases; mechanism of reaction; structural characteristics; on-line database
Description Glycosyltransferases catalyze the transfer of a sugar moiety from an activated donor sugar onto saccharide and non-saccharide acceptors. A sequence-based classification spreads glycosyltransferases in a large number of families thus reflecting the variety of molecules that can be used as acceptors. In contrast, this enzyme family is characterized by a more conserved 3D architecture. Until recently, only two different folds (GT-A and GT-B) have been identified for solved crystal structures. The recent report of a structure for a bacterial sialyltransferase allows the defination of a new fold family. Progress in the elucidation of the structures and mechanisms of glycosyltransferases are discussed in this review. To accomodate the growing number of crystal structures, the 3D-glycosyltransferase database has been created to gather structural information concerning this class of enzymes.
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