Antiaggressive and anxiogenic effects of MDMA in aggressive and timid singly housed mice
| Authors | |
|---|---|
| Year of publication | 2005 |
| Type | Article in Periodical |
| Magazine / Source | Behavioural Pharmacology |
| MU Faculty or unit | |
| Citation | |
| Field | Pharmacology and pharmaceutical chemistry |
| Keywords | MDMA; mice; agonistic interactions; anxiogenic effect |
| Description | We analyzed behavioural changes in 15 acts of 4 categories: sociable, timid, aggressive and locomotor. Mice were administered MDMA at the doses of 2.5 or 10 or 30 mg/kg, or saline in the equal amount of 1ml/kg, orally. Paired interactions were videotaped and ethological analysis was performed. In aggressive mice, MDMA in all tested doses caused highly significant inhibition of all aggressive activities with the significant increase of sociability and defensive-escape behaviour and at the highest dose also of walking. In timid mice, the most significant changes were in increase of defensive-escape behaviour and decrease of sociable activities; just the highest dose stimulated significantly walking. |
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