Effect of fluoxetine on methamphetamine biodegradation in methamphetamine dependence

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Authors

JUŘICA Jan DOSTÁLEK Miroslav PISTOVČÁKOVÁ Jana TOMANDL Josef LINHART Igor ŠULCOVÁ Alexandra HADAŠOVÁ Eva

Year of publication 2005
Type Article in Periodical
Magazine / Source European Neuropsychpharmacology
MU Faculty or unit

Faculty of Medicine

Citation
Field Pharmacology and pharmaceutical chemistry
Keywords metamphetamine; fluoxetine; dependence; pharmacokinetics
Description Fluoxetine and the combined treatment with methamphetamine inhibited oxidative metabolism by the CYP2C6 and CYP2D2 and CYP3A1/2. Fluoxetine therapy could slow down biodegradation of methamphetamine in methamphetamine dependent subjects and thus the psychotropic effect of the drug can be maintained by smaller doses.
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