Comparison of behavioural effects of amisulpride with selected antidepressants in the mouse model of social interactions

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Authors

PISTOVČÁKOVÁ Jana ŠULCOVÁ Alexandra

Year of publication 2005
Type Article in Periodical
Magazine / Source Homeostasis in Health and Diseases
MU Faculty or unit

Faculty of Medicine

Citation
Field Pharmacology and pharmaceutical chemistry
Keywords amisulpride; antidepressant; behaviour; agonistic interactions; social conflict; mice
Description The objective of this pre-clinical study was to ascertain behavioural effects of amisulpride in the model of agonistic interactions in mice and compare it with the effects of selected antidepressants in the same animal model. This model is principally based on the conspecific social conflict in male mice. In conclusion, unlike citalopram and valproate, amisulpride at the doses used did not produce antidepressant-like effects in this ethological model in mice, nor did it influence agonistic behaviour in the sense of anxiolytic effects.
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