Big endotelin,interleukin 6 a funkce pravé komory

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Title in English Big endothelin, interleukin 6 and right ventricle function
Authors

ŠPINAROVÁ Lenka TOMAN Jiří MELUZÍN Jaroslav HUDE Petr KREJČÍ Jan PAVELČÍKOVÁ Hana TOMANDL Josef VÍTOVEC Jiří

Year of publication 2005
Type Article in Periodical
Magazine / Source Vnitřní lékařství
MU Faculty or unit

Faculty of Medicine

Citation
Field Cardiovascular diseases incl. cardiosurgery
Keywords Big endothelin; interleukin 6; right ventricle
Description Objective: Big endothelin (BE) and interleukin 6 (IL 6) belong to important active substances, which are related to severity of heart failure. We compared patients with high and low levels of BE and IL 6 in relation to haemodynamics, left (LV) and right ventricle (RV) functions. Population: 155 patients with chronic heart failure, left ventricular ejection fraction (LVEF) below 40 %, NYHA II–IV, mean age 51.8 +- 8.8 years, 129 men, 26 women. 86 patients were diagnosed with ischaemic heart disease (IHD), 69 patients had dilatation cardiomyopathy (DCMP). Conclusion: Big endothelin and interleukin 6 levels are higher in patients who have systolic dysfunction of the left ventricle accompanied with more pronounced disorder of the right ventricle function than in patients who have disorder of the left cardiac ventricle only.
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