CREB-binding protein sensitizes v-myb-transformed monoblasts to differentiation inducers

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Authors

ŠMARDA Jan ŠMARDOVÁ Jana NEMAJEROVÁ Alice NAVRÁTILOVÁ Jarmila

Year of publication 2005
Type Article in Proceedings
Conference Functional Genomics and Disease
MU Faculty or unit

Faculty of Science

Citation
Field Oncology and hematology
Keywords CBP; Myb; differentiation; trichostatin A; TPA
Description CREB-binding protein (CBP) regulates gene expression by binding to certain components of basal transcription machinery and by histone acetylation. In addition, it integrates various cellular signaling pathways through binding to multiple transcription factors, including the Myb proteins. We report in this study that CBP can partially suppress function of the v-Myb oncoprotein in leukemic cells. Although originally described as activator of v-Myb function, we show that CBP can also act as v-Myb suppressor. Ectopic expression of murine CBP in v-Myb-transformed chicken monoblasts reduced transcriptional activation abilities of the v-Myb protein and increased sensitivity to differentiation inducers such as phorbol ester or trichostatin A. In addition, exogenous CBP affected morphology of differentiated cells derived from BM2 monoblasts. Altogether, these results indicate that cellular context is an important factor to determine whether CBP will activate or suppress the protein it targets.
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