Duálně působící antidepresiva
| Title in English | Dual-acting antidepressants |
|---|---|
| Authors | |
| Year of publication | 2005 |
| Type | Article in Periodical |
| Magazine / Source | Česká a slovenská psychiatrie |
| MU Faculty or unit | |
| Citation | |
| Field | Psychiatry, sexuology |
| Keywords | dual-acting antidepressants; venlafaxine; milnaciprane; duloxetine; mirtazapine; efficacy; tolerability; indication |
| Description | At first a history of development of antidepressants is mentioned. Dual-acting antidepressants are a relatively recent class of antidepressants. They include both serotonin and norepinephrine reuptake inhibitors (SNRI), e.g. venlafaxine, milnaciprane and duloxetine and a representative of noradrenergic and specific serotonergic antidepressants (NaSSA) mirtazapine. Further individual dual-acting antidepressants are compared including pharmacological profile, pharmacokinetics, efficacy and side effects. In some studies their profile of effectiveness was comparable to tricyclics and higher than SSRIs. They are better tolerated than tricyclics and simioar to SSRIs. They have also a higher rate of remissions and according to som e studies it seems that they have a faster onset of efficacy. Finally new indications of dual-acting antidepressant are cited, e.g. anxiety disorders and pain including depression associated pain. |
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