Cannabinoids did not affect sensitization to methamphetamine in rats
| Authors | |
|---|---|
| Year of publication | 2005 |
| Type | Article in Periodical |
| Magazine / Source | The World Journal of Biological Psychiatry |
| MU Faculty or unit | |
| Citation | |
| Field | Pharmacology and pharmaceutical chemistry |
| Keywords | behavioural sensitization; cannabinoids; methamphetamine; rats |
| Description | Obtained data clearly demonstrated that as previously in mice a repeated administration of methamphetamine elicited behavioural sensitization to its stimulatory effects in rats. However, we were not able to provoke cross-sensitization by repeated application of cannabinoid CB1 receptor agonist methanandamide and similarly, we did not demonstrate suppression of the cross-sensitization in rats that were repeatedly given combined pre-treatment of cannabinoid CB1 receptor antagonist AM 251 and methamphetamine as it was demonstrated in research carried out in mice. |
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