Genetic variability in the RAGE gene: Possible implications for nutrigenetics, nutrigenomics and understanding the susceptibility to diabetic complications
| Authors | |
|---|---|
| Year of publication | 2005 |
| Type | Article in Periodical |
| Magazine / Source | Molecular Nutrition & Food Research |
| MU Faculty or unit | |
| Citation | |
| Field | Endocrinology, diabetology, metabolism, nutrition |
| Keywords | AGEs; diabetes; glycoxidation; nutrigenetics; RAGE |
| Description | Complex chemical processes called non-enzymatic glycation and glycoxidation are one of the interesting examples of potentially harmful interaction between nutrition and disease. This review summarizes factors influencing the extent of glycoxidation in health and disease and especially focuses on the role of genetic variability in glycoxidation-related genes in disease and diet-related pathogenesis. Possible interaction between genetic variability in relevant loci and dietary Advanced Glycation End products (AGEs) is considered. As AGEs possess a wide range of chemical and biological effects, the interindividual functional variability in systems dealing with glycoxidation could have a significant nutrigenomic and nutrigenetic consequences. |
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