Interakcia haloperidolu s L-typom vápníkového kanála
| Title in English | Interaction of Haloperidol with L-type Voltage Dependent Calcium Channels |
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| Authors | |
| Year of publication | 2005 |
| Type | Article in Proceedings |
| Conference | Zborník prác a abstraktov prezentovaných na 81.Fyziologických doch |
| MU Faculty or unit | |
| Citation | |
| Field | Physiology |
| Keywords | voltage dependent calcium channel; haloperidol; sigma receptor |
| Description | Haloperidol is neuroleptic agent, effective in the treatment of various psychiatric disorders, such as schizophrenia or mania. Cardiac arrhythmias and other severe cardiovascular side effects have been associated with this therapy. We have investigated effects of haloperidol on currents through cardiac calcium channels in native tissue, i.e., in cardiomyocytes, and in expression system, i.e., in HEK 293 cell. Inhibition of inward currents through CaV1.2 calcium channels in model HEK 293 cells and in native cardiomyocytes by 10 ľmol/l haloperidol was observed. Used concentration was one order higher than therapeutic plasma concentration, therefore its expected effects in patients will be more subtle. Nevertheless, inhibition of cardiac calcium current still may contribute to observed side effects of haloperidol. |
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