Ion concentration changes in transverse-axial tubular system of rat and guinea pig ventricular cardiomyocytes: a simulation study

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Authors

PÁSEK Michal CHRISTÉ Georges ŠIMURDA Jiří

Year of publication 2004
Type Conference abstract
MU Faculty or unit

Faculty of Medicine

Citation
Description We explored the extent of ion concentration changes in the transverse-axial tubular system (TATS) of rat and guinea pig ventricular cardiomyocytes by means of mathematical models. The simulations revealed significant changes of tubular calcium and potassium concentrations at different stimulation rates. In the rat model, the transient depletion of tubular Ca2+ increased from 7.3 % to 14 % (related to external level) and the transient accumulation of tubular K+ decreased from 4.3 % to 3 % with increase of stimulation rate from 1 Hz to 5 Hz. The guinea pig model, on the contrary, exhibited decrease of tubular Ca2+ depletion from 15.6 % to 7.1 % and increase of tubular K+ accumulation from 2.5 % to 3.4 % in the same frequency-range.
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