Ion concentration changes in transverse-axial tubular system of rat and guinea pig ventricular cardiomyocytes: a simulation study

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Authors	PÁSEK Michal CHRISTÉ Georges ŠIMURDA Jiří
Year of publication	2004
Type	Conference abstract
MU Faculty or unit	Faculty of Medicine
Citation
Description	We explored the extent of ion concentration changes in the transverse-axial tubular system (TATS) of rat and guinea pig ventricular cardiomyocytes by means of mathematical models. The simulations revealed significant changes of tubular calcium and potassium concentrations at different stimulation rates. In the rat model, the transient depletion of tubular Ca2+ increased from 7.3 % to 14 % (related to external level) and the transient accumulation of tubular K+ decreased from 4.3 % to 3 % with increase of stimulation rate from 1 Hz to 5 Hz. The guinea pig model, on the contrary, exhibited decrease of tubular Ca2+ depletion from 15.6 % to 7.1 % and increase of tubular K+ accumulation from 2.5 % to 3.4 % in the same frequency-range.
Related projects:	Quantitative analysis of effect of tubular system on electrical activity of cardiac cells