Action potential voltage clamp method used in analysis of rate-dependent changes of action potential

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Authors

BÉBAROVÁ Markéta MATEJOVIČ Peter PÁSEK Michal ŠIMURDOVÁ Milena ŠIMURDA Jiří

Year of publication 2004
Type Article in Periodical
Magazine / Source Analysis of Biomedical Signals and Images
MU Faculty or unit

Faculty of Medicine

Citation
Field Physiology
Keywords action potential voltage clamp; rate dependence; method; action potential
Description Ionic currents responsible for rate-dependent changes of action potetial (AP) waveform were analyzed using AP voltage clamp method in isolated rat ventricular myocytes. The L-type calcium current ICa-L and the transient outward current Ito were found to underlie rate-dependent variability of AP duration. In addition, the fast sodium current INa played a significant role under the effect of the class I antiarrhythmic drug ajmaline, very likely as a consequence of its use-dependent block.
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