Interspecies comparison of sensitization to methamphetamine effects on locomotion in mice and rats.

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Authors

LANDA Leoš ŠLAIS Karel HANESOVÁ Mariana ŠULCOVÁ Alexandra

Year of publication 2005
Type Article in Periodical
Magazine / Source Psychiatrie
MU Faculty or unit

Faculty of Medicine

Citation
Field Pharmacology and pharmaceutical chemistry
Keywords behavioural sensitization; methamphetamine; rat; mouse
Description Repeated exposure to drugs of abuse results in a typical progressive enhancement of their behavioural effects, namely stimulation of locomotion and occurrence of stereotypies. This phenomenon is termed behavioural sensitization. In our previous study we confirmed sensitization to methamphetamine (Met) stimulatory effects on locomotion in mice using our original dosage regimen. To investigate possible interspecies differences in susceptibility to drug sensitization we applied the same experimental design to rats.
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