Integrins regulate survival of pre-B-ALL cells through differential IAP and caspase-7 ubiquitination and degradation.

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Authors

ASTIER Anne SVOBODA Marek HINDS Esther DE BEAUMONT Rosalie MUNOZ Olivier FREEDMAN Arnold Stephen

Year of publication 2004
Type Article in Periodical
Magazine / Source Leukemia
MU Faculty or unit

Faculty of Medicine

Citation
Field Oncology and hematology
Keywords Leukemia;Apoptosis;IAPs;Ubiquitination;Microarrays;Caspases
Description The interactions between integrins and their ligands rescue normal and neoplastic B cells from apoptosis in several ways. The first we have found that integrin stimulation enhances the amount of antiapoptotic proteins from the IAP family members. Second, to further control the levels of these proteins, integrins regulate their proteasomal degradation by controlling their level of ubiquitination. Indeed, the understanding of the well-defined mechanisms controlling apoptosis might provide future therapeutic strategies to modulate the survival of neoplastic B cells.

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