Výskyt a léčba relapsu dětské akutní lymfoblastické leukémie v České republice v letech 1990-2000
| Title in English | The incidence and teatment of relapse of childhood acute lymphoblastic leukemia in the Czech Republic between 1990-2000 |
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| Authors | |
| Year of publication | 2003 |
| Type | Article in Periodical |
| Magazine / Source | Transfuze a hematologie dnes |
| MU Faculty or unit | |
| Citation | |
| Field | Paediatry |
| Keywords | acute lymphoblastic leukemia; relapse; children; stem-cell transplantation; chemotherapy; BFM protocol |
| Description | Successful teratment of relapsed acute lympholastic leukemia (ALL) is one of the biggest challenges in pediatric hematooncology at the beginning of the 21st century. The authors analyze a group of 85 children suffering first relapse of ALL in the Czech Republic between 1990-2000. The probability of 4-year event-free survival (EFS) was 16,7%(SE 5%) and that of overall survival 22,8% (SE 5%) for the whole group. In the 1996 treatment of children with relapse of ALL was unified according to the German protocol ALL-REZ BFM 96. Twenty-six (47,3%) out of 55 children achieving cesond remission were treated by chemotherapy alone, 21 (38,2%)children underwent allogeneic stem-cell transplatation |