Výskyt a léčba relapsu dětské akutní lymfoblastické leukémie v České republice v letech 1990-2000

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Title in English The incidence and teatment of relapse of childhood acute lymphoblastic leukemia in the Czech Republic between 1990-2000
Authors

STARÝ Jan GAJDOŠ P. SEDLÁČEK Ivo PROCHÁZKOVÁ Dagmar HRSTKOVÁ Hana KOPEČNÁ Lenka HAK J. VÁVRA Václav ZŮNA Jiří HRUŠÁK Petr SMÍŠEK P.

Year of publication 2003
Type Article in Periodical
Magazine / Source Transfuze a hematologie dnes
MU Faculty or unit

Faculty of Science

Citation
Field Paediatry
Keywords acute lymphoblastic leukemia; relapse; children; stem-cell transplantation; chemotherapy; BFM protocol
Description Successful teratment of relapsed acute lympholastic leukemia (ALL) is one of the biggest challenges in pediatric hematooncology at the beginning of the 21st century. The authors analyze a group of 85 children suffering first relapse of ALL in the Czech Republic between 1990-2000. The probability of 4-year event-free survival (EFS) was 16,7%(SE 5%) and that of overall survival 22,8% (SE 5%) for the whole group. In the 1996 treatment of children with relapse of ALL was unified according to the German protocol ALL-REZ BFM 96. Twenty-six (47,3%) out of 55 children achieving cesond remission were treated by chemotherapy alone, 21 (38,2%)children underwent allogeneic stem-cell transplatation

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