Differential effects of v-Jun and c-Jun proteins on v-myb-transformed monoblasts

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Authors

ŠEVČÍKOVÁ Sabina SOUČEK Karel KUBALA Lukáš BRYJA Vítězslav ŠMARDA Jan

Year of publication 2002
Type Article in Periodical
Magazine / Source Cellular and Molecular Life Sciences
MU Faculty or unit

Faculty of Science

Citation
Field Genetics and molecular biology
Keywords v-Myb; Jun; differebtiation; proliferation; retinoic acid; phorbol ester
Description The line of v-myb-transformed chicken monoblats BM2 can be induced to terminal differentiation using phorbol esters. The fact that Jun proteins are up-regulated in the phorbol ester-treated BM2 cells promptred us to investigate the role of the Jun proteins in regulation of myeloid differentiation. We ectopically expressed v-jun and c-jun in BM2 cells and evaluated their effects on differentiation, proliferation and apoptosis.
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