NMR methodology for the study of nucleic acids

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Authors

ŽÍDEK Lukáš ŠTEFL Richard SKLENÁŘ Vladimír

Year of publication 2001
Type Article in Periodical
Magazine / Source Current Opinion in Structural Biology
MU Faculty or unit

Faculty of Science

Citation
Field Biophysics
Keywords NMR; nucleic acids; NMR methods; review
Description During the past few years, NMR methodology for the studey of nucleic acids has benefited from new developments that greatly improved state-of-the-art technology for the precise determination of three-dimensional structures. Substantial progress has been made in designing experimental protocols for the measurement of residual dipolar couplings, in sensitivity optimization for triple-resonance experiments and in detection of hydrogen bonds in developing computational methods for structure refinement using NMR restraints.
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