Duration of NIDDM and the TNFb NcoI genotype as predictive factors in proliferative diabetic retinopathy
| Authors | |
|---|---|
| Year of publication | 2001 |
| Type | Article in Periodical |
| Magazine / Source | Ophthalmologica |
| MU Faculty or unit | |
| Citation | |
| Field | Genetics and molecular biology |
| Description | The object of the study was to investigate the share of polymorphisms I/D ACE, endothelin-1 4127G/A and TNFb NcoI in the susceptibility to proliferative diabetic retinopathy (PDR) in non-insulin dependent diabetes mellitus (NIDDM). Genotypes were detected by polymerase chain reactions and determined in a set of 246 Caucasian NIDDM subjects with defined PDR status. The relevance of genotypes and clinical characteristics to the PDR occurrence was tested using multiple linear regression models and discrimination analysis. The best predictive value for PDR was given by a combination of two parameters - NIDDM duration and the TNFb genotype (P<1*10-6 and P=1*10-2, respectively) with a correct retrograde prediction of 82.6%. A comparison of the TNFb NcoI allele frequencies revealed no difference between NIDDM and nondiabetic subjects (n=176), but a statistically significant difference was found between PDR and non-PDR NIDDM subjects (after a correction for the number of comparisons P=0.03); allele b2 being associated with PDR. Our results identified the allele variant TNFb2 being associated with PDR in NIDDM. Diabetes duration and the TNFb NcoI genotype were proved to significantly predict PDR occurrence. The TNFb2 allele could be regarded as a separate genetic risk factor that increases the relative incidence of PDR in patients with NIDDM. |
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