Polymorphisms in inflammation genes(angiotensinogen, TAP1 and TNF-beta) in psoriasis
| Title in English | Polymorphisms in inflammatin genes(angiotensinogen,TAP1 and TNF-beta) in psoriasis |
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| Authors | |
| Year of publication | 2000 |
| Type | Article in Periodical |
| Magazine / Source | Archives of Dermatological Research |
| MU Faculty or unit | |
| Citation | |
| Field | Dermatovenerology |
| Keywords | psoriasis; gene polymorphism; 6p21.3; angiotensinogen; TNF-beta; TAP1; 1q42 |
| Description | This study focused on the association between plaque psoriasis and polymorphisms of several inflamation genes [M235T ATG, A(-6)G ATG], in transporters associated with antigen processing TAP1 (TAP1*0101, TAP*02011 and TAP1*0301 and TNF-beta(NcoI in promoter). Included in the study were 142 Caucasian (Czech)patients with plaque psoriasis and 141 healthy subjects. An increase in B1 allele of NcoI TNF-beta polymorphism was found in psoriatic patients compared to healthy individuals (odds ratio = 1.6; 95% confidence interval 1.13-2.26; P = 0.006). A positive family history of psoriasis was associated with a higher B1 allele frequency in NcoI TNF-beta (P=0.01). A case-control difference was found in the allelic concurrence of M235T and A(-6)G ATG polymorphisms. The most frequent population genotypes MMGG, MTAG and TTAA were observed in 92% of patients vs 74% of control subjects (odds ratio 0,29; 95% confidence interval 0,14-0,60; P = 0.0003). |
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