Polymorphisms in inflammation genes(angiotensinogen, TAP1 and TNF-beta) in psoriasis

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Title in English Polymorphisms in inflammatin genes(angiotensinogen,TAP1 and TNF-beta) in psoriasis
Authors

VAŠKŮ Vladimír VAŠKŮ Anna IZAKOVIČOVÁ HOLLÁ Lydie TSCHÖPLOVÁ Svatava KAŇKOVÁ Kateřina BENÁKOVÁ Nina SEMRÁDOVÁ Věra

Year of publication 2000
Type Article in Periodical
Magazine / Source Archives of Dermatological Research
MU Faculty or unit

Faculty of Medicine

Citation
Field Dermatovenerology
Keywords psoriasis; gene polymorphism; 6p21.3; angiotensinogen; TNF-beta; TAP1; 1q42
Description This study focused on the association between plaque psoriasis and polymorphisms of several inflamation genes [M235T ATG, A(-6)G ATG], in transporters associated with antigen processing TAP1 (TAP1*0101, TAP*02011 and TAP1*0301 and TNF-beta(NcoI in promoter). Included in the study were 142 Caucasian (Czech)patients with plaque psoriasis and 141 healthy subjects. An increase in B1 allele of NcoI TNF-beta polymorphism was found in psoriatic patients compared to healthy individuals (odds ratio = 1.6; 95% confidence interval 1.13-2.26; P = 0.006). A positive family history of psoriasis was associated with a higher B1 allele frequency in NcoI TNF-beta (P=0.01). A case-control difference was found in the allelic concurrence of M235T and A(-6)G ATG polymorphisms. The most frequent population genotypes MMGG, MTAG and TTAA were observed in 92% of patients vs 74% of control subjects (odds ratio 0,29; 95% confidence interval 0,14-0,60; P = 0.0003).
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