Některé genetické aspekty kožních T-lymfomů.

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Title in English Some genetic aspects of cutaneous T-cell lymphomas
Authors

VAŠKŮ Vladimír VAŠKŮ Anna IZAKOVIČOVÁ HOLLÁ Lydie TSCHÖPLOVÁ Svatava VÁCHA Jiří SEMRÁDOVÁ Věra

Year of publication 2000
Type Article in Periodical
Magazine / Source Česko-slovenská dermatologie
MU Faculty or unit

Faculty of Medicine

Citation
Field Dermatovenerology
Keywords ACE; TNF; cutaneous T-cell lymphoma; gene polymorphism
Description The study was focused on an association between T-cell lymphoma and some supposed components of genetic background of the organism which could participate in the onset of cutaneous T-cell lymphomas. Polymorphisms of angiotensinogen I-converting enzyme (I/D ACE) and lymphotoxin alpha (NcoI TNF beta) genes were investigated in 33 Caucasian patients with cutaneous T-cell lymphomas and 66 healthy subjects using PCR methods and restriction enzyme analysis. In patients with T-Cell lymphoma, a concurrence of DD genotype of I/D ACE with B1 allele of TNF beta gene polymorphism was found(n=2/24, 8% in controls vs. n=8/18, 44% in CTCL, P=0.009, odds ratio=8.80, 95% confidence interval 1.50-51.50). The DD homozygote together with TNF beta heterozygote genotype (DDB1B2) was found to be the highest risk genotype for T-cell lymphoma patients (n=2/12, 17% in controls and 8/9, 89% in CTCL, P=0.002, odds ratio 40.00, 95% confidence interval 1.56-1024.12.
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