Functional ralationship between enzymes MAOA and ACE in human brain?
| Authors | |
|---|---|
| Year of publication | 2000 |
| Type | Article in Periodical |
| Magazine / Source | European psychiatry |
| MU Faculty or unit | |
| Citation | |
| Field | Physiology |
| Keywords | MAOA ACE polymorphism functional relationship neuropsychiatric disorders |
| Description | We first time tried the relationship between polymorphic sites in genes of two enzymes, which are participating in the regulation of the dopamine system of the brain. We did found statistically significant more prevalent presence of long alleles of MAOA polymorphism with I allele of ACE polymorphism and presence of short alleles of MAOA polymorphism with D allele of ACE polymorphism. We propose that combinations of studied polymorphisms can participate in the balancing of MAOA activity and in dopamine system. |
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