Functional ralationship between enzymes MAOA and ACE in human brain?

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Authors

ŠERÝ Omar ZNOJIL Vladimír MIKEŠ Vladimír ZVOLSKÝ Petr

Year of publication 2000
Type Article in Periodical
Magazine / Source European psychiatry
MU Faculty or unit

Faculty of Science

Citation
Field Physiology
Keywords MAOA ACE polymorphism functional relationship neuropsychiatric disorders
Description We first time tried the relationship between polymorphic sites in genes of two enzymes, which are participating in the regulation of the dopamine system of the brain. We did found statistically significant more prevalent presence of long alleles of MAOA polymorphism with I allele of ACE polymorphism and presence of short alleles of MAOA polymorphism with D allele of ACE polymorphism. We propose that combinations of studied polymorphisms can participate in the balancing of MAOA activity and in dopamine system.
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