Anion Transport by Bambusuril-Bile Acid Conjugates: Drastic Effect of the Cholesterol Content

Warning

This publication doesn't include Faculty of Sports Studies. It includes Faculty of Science. Official publication website can be found on muni.cz.

Authors	TORRISI Jacopo CHVOJKA Matúš JURČEK Pia Yasmine ZHANG Xinxin ZENG Huaqiang ŠINDELÁŘ Vladimír VALKENIER Hennie
Year of publication	2025
Type	Article in Periodical
Magazine / Source	Angewandte Chemie International Edition
MU Faculty or unit	Faculty of Science
Citation
web	https://onlinelibrary.wiley.com/doi/10.1002/anie.202424754
Doi	http://dx.doi.org/10.1002/anie.202424754
Keywords	Supramolecular Chemistry; Anion transport; Anion Channels; Macrocycles; Bambusurils
Attached files	2483224.pdf
Description	Artificial anion transporters offer a potential way to treat deficiencies in cellular anion transport of genetic origins. In contrast to the large variety of mobile anion carriers and self-assembled anion channels reported, unimolecular anion channels are less investigated. Herein, we present a unique example of a unimolecular anion channel based on a bambusuril (BU) macrocycle, a well-established anion receptor. The BU structure was expanded by appending various bile acid residues allowing a single molecule to span the membrane. Chloride transport mediated by BUs through lipid bilayers was investigated in liposomes and these studies revealed a surprisingly high dependence of the anion transport activity on the cholesterol content in the liposomal membrane.
Related projects:	CETOCOEN Excellence Czech Infrastructure for Integrative Structural Biology Chemical modification of bambusurils for adjusting their binding affinity and selectivity Národní infrastruktura chemické biologie RECETOX research infrastructure