Zmeny elektrickej aktivity podmienené neurodegeneráciou

• Title in English: Changes in the electrical activity caused by neurodegeneration
• Authors: LIŠČÁKOVÁ Barbora; ANGELOVSKI Andrijana; ŠVECOVÁ Olga; HŘÍBKOVÁ Hana; SEDMÍK Jiří; BOHAČIAKOVÁ Dáša; KLIMEŠ Petr; KOLAJOVÁ Martina; BRÁZDIL Milan; BÉBAROVÁ Markéta
• Year of publication: 2024
• Type: Conference abstract
• MU Faculty or unit: Faculty of Medicine
• Description: Higher number of active electrodes, longer burst duration, and higher number of spikes in burst have been detected in Ad vs. WT organoids. The increased electrical activity observed in AD organoids suggested a relationship between AD and hyperexcitability.

Related projects

• The role of neurodegeneration in pathogenesis, manifestations and prognosis of MTLE/HS - in vivo, ex vivo and in vitro perspective
• Národní ústav pro neurologický výzkum
• Constructing the Developmental Atlas of Alzheimer’s Disease using Cerebral Organoids and Single-Cell Transcriptomics
• Analysis of (dys)function: from molecules to the living organism