Association of BMI, lipid-lowering medication, and age with prevalence of type 2 diabetes in adults with heterozygous familial hypercholesterolaemia: a worldwide cross-sectional study

• Authors: ELSHORBAGY Amany; LYONS Alexander R M; VALLEJO-VAZ Antonio J; STEVENS Christophe A T; DHARMAYAT Kanika I; BRANDTS Julia; CATAPANO Alberico L; FREIBERGER Tomáš; HOVINGH G Kees; MATA Pedro; RAAL Frederick J; SANTOS Raul D; SORAN Handrean; WATTS Gerald F; ABIFADEL Marianne; AGUILAR-SALINAS Carlos A; ALHABIB Khalid F; ALKHNIFSAWI Mutaz; ALMAHMEED Wael; ALNOURI Fahad; ALONSO Rodrigo; AL-RASADI Khalid; AL-SARRAF Ahmad; ASHAVAID Tester F; BANACH Maciej; BINDER Christoph J; BOURBON Mafalda; BRUNHAM Liam R; CHLEBUS Krzysztof; CORRAL Pablo; CRUZ Diogo; DAVLETOV Kairat; DESCAMPS Olivier S; EZHOV Marat; GAITA Dan; GROSELJ Urh; HARADA-SHIBA Mariko; HOLVEN Kirsten B; KAYIKCIOGLU Meral; KHOVIDHUNKIT Weerapan; LALIC Katarina; LATKOVSKIS Gustavs; LAUFS Ulrich; LIBEROPOULOS Evangelos; LIMA-MARTINEZ Marcos M; LIN Jie; MAHER Vincent; MARAIS A David; MARZ Winfried; MIRRAKHIMOV Erkin; MISEREZ Andre R; MITCHENKO Olena; NAWAWI Hapizah; NORDESTGAARD Borge G; PANAYIOTOU Andrie G; PARAGH Gyorgy; PETRULIONIENE Zaneta; POJSKIC Belma; POSTADZHIYAN Arman; REDA Ashraf; REINER Zeljko; REYES Ximena; SADIQ Fouzia; SADOH Wilson E; SCHUNKERT Heribert; SHEK Aleksandr B; STROES Erik; SU Ta-Chen; SUBRAMANIAM Tavintharan; SUSEKOV Andrey V; TILNEY Myra; TOMLINSON Brian; THANH-HUONG Truong; TSELEPIS Alexandros D; TYBJAERG-HANSEN Anne; VAZQUEZ Alejandra C; VIIGIMAA Margus; VOHNOUT Branislav; WANG Luya; YAMASHITA Shizuya; ARCA Marcello; AVERNA Maurizio; RAY Kausik K
• Year of publication: 2024
• Type: Article in Periodical
• Magazine / Source: LANCET DIABETES & ENDOCRINOLOGY
• MU Faculty or unit: Faculty of Medicine
• web: https://www.thelancet.com/journals/landia/article/PIIS2213-8587%2824%2900221-3/fulltext
• Doi: http://dx.doi.org/10.1016/S2213-8587(24)00221-3
• Keywords: BMI; lipid-lowering medication; age; type 2 diabetes; heterozygous familial hypercholesterolaemia

Attached files

• Association_of_BMI__lipid-lowering_medication__and_age_with_prevalence_of_type_2_diabetes_in_adults_with_heterozygous_familial_hypercholesterolaemia_a_worldwide_cross-sectional_study.pdf

• Description: Background Statins are the cornerstone treatment for patients with heterozygous familial hypercholesterolaemia but research suggests it could increase the risk of type 2 diabetes in the general population. A low prevalence of type 2 diabetes was reported in some familial hypercholesterolaemia cohorts, raising the question of whether these patients are protected against type 2 diabetes. Obesity is a well known risk factor for the development of type 2 diabetes. We aimed to investigate the associations of known key determinants of type 2 diabetes with its prevalence in people with heterozygous familial hypercholesterolaemia.

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