The use of micro-CT and histological analysis in the diagnosis of Paget's disease

• Authors: VAŇATKOVÁ Kateřina; VARGOVÁ Lenka; HORÁČKOVÁ Ladislava; NEMĚČKOVÁ Alena; VYMAZALOVÁ Kateřina; MACHÁČEK Jiří; VOPÁLENSKÝ Michal; ADÁMKOVÁ Irena; JILMOVÁ Dagmar
• Year of publication: 2024
• Type: Conference abstract
• MU Faculty or unit: Faculty of Medicine
• Citation: VAŇATKOVÁ, Kateřina, Lenka VARGOVÁ, Ladislava HORÁČKOVÁ, Alena NEMĚČKOVÁ, Kateřina VYMAZALOVÁ, Jiří MACHÁČEK, Michal VOPÁLENSKÝ, Irena ADÁMKOVÁ and Dagmar JILMOVÁ. The use of micro-CT and histological analysis in the diagnosis of Paget's disease. In Annual PhD Conference in Biomedical Sciences, 2024. 2024.
• Description: Paget's disease is a metabolic disease of unclear etiology, characterized by excessive bone resorption followed by the formation of structurally deficient bone. The most commonly affected bones are the vertebral column, pelvis, femur, skull, and sacrum. The disease manifests itself in the fifth or sixth decade of life. The current incidence in the Czech Republic is approximately 3?% and it is one of the most common metabolic diseases. However, findings on historical skeletal remains are still rare. During archaeological research in Líbivá near Břeclav, possible manifestations of Paget's disease were observed on one of the skeletons. The skeletal remains of a male about 60 years old, subjected to anthropological and palaeopathological analyses, had significant pathological changes on the skull, vertebrae, long bones, and rib. On the postcranial skeleton, the spongiosis of the long bones was quite abundant, diploe of the skull was wide and showed a pumicelike structure. The histological examination of bone tissue sections revealed a mosaic pattern. Micro-CT of the cranial vault showed, that the bone has lost its homogeneous structure, with a clearing at the site of osteolytic foci, thickening at the site of new bone formation, and only sporadically there are fragments of normal bone tissue.