Chronic citalopram effects on the brain neurochemical profile and perfusion in a rat model of depression detected by the NMR techniques – spectroscopy and perfusion

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Authors	PAVLOVA Iveta DRAŽANOVÁ Eva KRÁTKÁ Lucie AMCHOVÁ Petra HRICKOVÁ Mária MACÍČEK Ondřej VITOUŠ Jiří JIŘÍK Radovan RUDÁ Jana
Year of publication	2024
Type	Article in Periodical
Magazine / Source	Biomedicine and Pharmacotherapy
MU Faculty or unit	Faculty of Medicine
Citation
web	https://www.sciencedirect.com/science/article/pii/S0753332224015427
Doi	http://dx.doi.org/10.1016/j.biopha.2024.117656
Keywords	Citalopram; Depression; Brain metabolites; Olfactory bulbectomy; Cerebral perfusion; Rats
Description	Collectively, 1H MRS and rCBF approaches demonstrated their capacity to capture an OB-induced phenotype and chronic antidepressant treatment effect in multiple brain regions.
Related projects:	National research infrastructure for biological and medical imaging Multi-Contrast Quantification of Perfusion Using Joint Magnetic Resonance Contrast-Enhanced and Arterial-Spin-Labeling Approaches Czech BioImaging: National research infrastructure for biological and medical imaging Preclinical and clinical research of the Department of Pharmacology in the field of biotransformation of drugs, behavioural neuropsychopharmacology and personalized pharmacotherapy in oncology