The role of coatings and plasticizers compatibility in stability of advanced gastro-resistant self-emulsifying pellets designed for the delivery of volatile compounds: A combined solid-state NMR and dissolution study

• Authors: MACKŮ Jan; VYSLOUŽIL Jakub; MUSELÍK Jan; PAVELKOVÁ Miroslava; VETCHÝ David; HLAVATÁ Daniela; MIROSLAV Šlouf; ČUBOVÁ URBANOVÁ Martina; BRUS Jiří; KUBOVÁ Kateřina
• Year of publication: 2024
• Type: Article in Periodical
• Magazine / Source: JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
• MU Faculty or unit: Faculty of Pharmacy
• Web: https://www.sciencedirect.com/science/article/pii/S1773224724009948
• Doi: http://dx.doi.org/1016/j.jddst.2024.106325
• Keywords: Self-emulsifying pellets; Eudragit® L 30 D-55; Triethyl citrate; Plasticizer; Thymol; Stability
• Description: The gastro-resistant behaviour of solid self-emulsifying drug delivery systems (S-SEDDS) represents a significant and innovative advancement in delivering poorly soluble drugs. Due to the complexity of these systems and the liquid nature of SEDDS, thorough investigation is essential. This study explored the stability of self-emulsifying (SE) pellets containing the volatile compound thymol coated with gastro-resistant Eudragit® L 30 D-55 water dispersion.

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