Iron chelators as mitophagy agents: Potential and limitations
| Authors | |
|---|---|
| Year of publication | 2024 |
| Type | Article in Periodical |
| Magazine / Source | BIOMEDICINE & PHARMACOTHERAPY |
| MU Faculty or unit | |
| Citation | BROGYANYI, Tereza, Zdenek KEJIK, Katerina VESELA, Petr DYTRYCH, David HOSKOVEC, Michal MASAŘÍK, Petr BABULA, Robert KAPLANEK, Tomas PRIBYL, Jaroslav ZELENKA, Tomas RUML, Martin VOKURKA, Pavel MARTASEK and Milan JAKUBEK. Iron chelators as mitophagy agents: Potential and limitations. BIOMEDICINE & PHARMACOTHERAPY. PARIS: ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2024, vol. 179, October 2024, p. 1-29. ISSN 0753-3322. Available from: https://dx.doi.org/10.1016/j.biopha.2024.117407. |
| web | https://www.sciencedirect.com/science/article/pii/S0753332224012927?via%3Dihub |
| Doi | http://dx.doi.org/10.1016/j.biopha.2024.117407 |
| Keywords | Mitophagy; Iron heomeostais; Iron chelators; Cancer; Neurodegenerative diseases; Cardiovascular diseases |
| Attached files | |
| Description | Mitochondrial autophagy (mitophagy) is very important process for the maintenance of cellular homeostasis, functionality and survival. Its dysregulation is associated with high risk and progression numerous serious diseases (e.g., oncological, neurodegenerative and cardiovascular ones). Therefore, targeting mitophagy mechanisms is very hot topic in the biological and medicinal research. The interrelationships between the regulation of mitophagy and iron homeostasis are now becoming apparent. In short, mitochondria are central point for the regulation of iron homeostasis, but change in intracellular cheatable iron level can induce/repress mitophagy. In this review, relationships between iron homeostasis and mitophagy are thoroughly discussed and described. Also, therapeutic applicability of mitophagy chelators in the context of individual diseases is comprehensively and critically evaluated. |
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