Reply to: Questioning the cycad theory of Kii ALS-PDC causation

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Authors	MENSIKOVA Katerina ROSALES Raymond COLOSIMO Carlo SPENCER Peter LANNUZEL Annie UGAWA Yoshikazu SASAKI Ryogen GIMENEZ-ROLDAN Santiago MATEJ Radoslav TUCKOVA Lucie HRABOS Dominik KOLARIKOVA Kristyna VODICKA Radek VRTEL Radek STRNAD Miroslav HLUSTIK Petr OTRUBA Pavel PROCHAZKA Martin BAREŠ Martin BOLUDA Susana BUEE Luc RANSMAYR Gerhard KANOVSKY Petr
Year of publication	2024
Type	Article in Periodical
Magazine / Source	NATURE REVIEWS NEUROLOGY
MU Faculty or unit	Faculty of Medicine
Citation
web	https://www.nature.com/articles/s41582-024-00938-y
Doi	http://dx.doi.org/10.1038/s41582-024-00938-y
Keywords	Kii ALS–PDC causation; cycad theory
Description	We read with great interest the Correspondence to our recent Review (Menšíková, K. et al. Endemic parkinsonism: clusters, biology and clinical features. Nat. Rev. Neurol. 19, 599–616 (2023)) by Kokubo and colleagues (Kokubo, Y., Morimoto, S. & Yoshida, M. Questioning the cycad theory of Kii ALS–PDC causation. Nat. Rev. Neurol. https://doi.org/10.1038/s41582-024-00936-0 (2024)). We are aware that Kokubo — together with the late S. Kuzuhara — systematically studied amyotrophic lateral sclerosis–parkinsonism–dementia complex (ALS–PDC) on the Kii Peninsula for more than 30 years. They authored and co-authored numerous papers about this endemic disease, some of them with one of us (R.S.). We therefore considered the comments raised by Kokubo et al. carefully, and here we respond to the questions that they have raised.