ELIXIR and Toxicology: a community in development [version 2; peer review: 2 approved]

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Authors

MARTENS Marvin STIERUM Rob SCHYMANSKI Emma L. EVELO Chris T. AALIZADEH Reza ALADJOV Hristo ARTURI Kasia AUDOUZE Karine BABICA Pavel BERKA Karel BESSEMS Jos BLÁHA Luděk BOLTON Evan E. CASES Montserrat DAMALAS Dimitrios ?. DAVE Kirtan DILGER Marco EXNER Thomas GEERKE Daan P. GRAFSTRÖM Roland GRAY Alasdair HANCOCK John M. HOLLERT Henner JELIAZKOVA Nina JENNEN Danyel JOURDAN Fabien KAHLEM Pascal KLÁNOVÁ Jana KLEINJANS Jos KONDIC Todor KONE Boi LYNCH Iseult MARAN Uko CUESTA Sergio Martinez MÉNAGER Hervé NEUMANN Steffen NYMARK Penny OBERACHER Herbert RAMIREZ Noelia REMY Sylvie ROCCA-SERRA Philippe SALEK Reza M. SALLACH Brett SANSONE Susanna-Assunta SANZ Ferran SARIMVEIS Haralambos SARNTIVIJAI Sirarat SCHULZE Tobias SLOBODNIK Jaroslav SPJUTH Ola TEDDS Jonathan THOMAIDIS Nikolaos WEBER Ralf J.M. VAN WESTEN Gerard J.P. WHEELOCK Craig E. WILLIAMS Antony J. WITTERS Hilda ZDRAZIL Barbara ŽUPANIČ Anže

Year of publication 2023
Type Article in Periodical
Magazine / Source F1000Research
MU Faculty or unit

Faculty of Science

Citation
Web https://f1000research.com/articles/10-1129/v2
Doi http://dx.doi.org/10.12688/f1000research.74502.2
Keywords ELIXIR; FAIR; interoperability; Toxicology
Description Toxicology has been an active research field for many decades, with academic, industrial and government involvement. Modern omics and computational approaches are changing the field, from merely disease-specific observational models into target-specific predictive models. Traditionally, toxicology has strong links with other fields such as biology, chemistry, pharmacology, and medicine. With the rise of synthetic and new engineered materials, alongside ongoing prioritisation needs in chemical risk assessment for existing chemicals, early predictive evaluations are becoming of utmost importance to both scientific and regulatory purposes. ELIXIR is an intergovernmental organisation that brings together life science resources from across Europe. To coordinate the linkage of various life science efforts around modern predictive toxicology, the establishment of a new ELIXIR Community is seen as instrumental. In the past few years, joint efforts, building on incidental overlap, have been piloted in the context of ELIXIR. For example, the EU-ToxRisk, diXa, HeCaToS, transQST, and the nanotoxicology community have worked with the ELIXIR TeSS, Bioschemas, and Compute Platforms and activities. In 2018, a core group of interested parties wrote a proposal, outlining a sketch of what this new ELIXIR Toxicology Community would look like. A recent workshop (held September 30th to October 1st, 2020) extended this into an ELIXIR Toxicology roadmap and a shortlist of limited investment-high gain collaborations to give body to this new community. This Whitepaper outlines the results of these efforts and defines our vision of the ELIXIR Toxicology Community and how it complements other ELIXIR activities.
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