Structural conservation of antibiotic interaction with ribosomes

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Authors	PATERNOGA Helge CROWE-MCAULIFFE Caillan BOCK Lars V KOLLER Timm O MORICI Martino BECKERT Bertrand MYASNIKOV Alexander G GRUBMUELLER Helmut NOVÁČEK Jiří WILSON Daniel N
Year of publication	2023
Type	Article in Periodical
Magazine / Source	NATURE STRUCTURAL & MOLECULAR BIOLOGY
MU Faculty or unit	Central European Institute of Technology
Citation
web	https://www.nature.com/articles/s41594-023-01047-y
Doi	http://dx.doi.org/10.1038/s41594-023-01047-y
Keywords	ribosome; antibiotics; CryoEM; antibiotic–ribosome interactions; RNA-targeting therapies
Description	Here the authors present the high-resolution structures of 17 antibiotics bound to Escherichia coli ribosomes, which may inform the development of new antibacterial agents. Their results unveil a conserved manner of antibiotic binding to the ribosome, including ordered water molecules.
Related projects:	iNEXT-Discovery: Infrastructure for transnational access and discovery in integrated structural biology Modernization of the Czech Infrastructure for Integrative Structural Biology CIISB - Czech Infrastructure for Integrative Structural Biology