Early-onset pancreatic cancer: A national cancer registry study from the Czech Republic and review of the literature

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Authors	WHITLEY Adam KOCIAN Petr NIKOV Andrej KREJČÍ Denisa KŮSOVÁ Lucie BLAHA Milan DUŠEK Ladislav GURLICH Robert
Year of publication	2023
Type	Article in Periodical
Magazine / Source	JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
MU Faculty or unit	Faculty of Medicine
Citation
Web	https://onlinelibrary.wiley.com/doi/10.1002/jhbp.1359
Doi	http://dx.doi.org/10.1002/jhbp.1359
Keywords	adult; pancreatic neoplasms; population register; survival; young adult
Description	Background: The aim of this study was to compare trends in mortality and incidence, clinicopathological features and survival of patients diagnosed with pancreatic ductal adenocarcinoma under 50 years of age (early-onset pancreatic cancer [EOPC]) with patients diagnosed over 50 years of age (late-onset pancreatic cancer [LOPC]).Methods: The national oncological registry of the Czech Republic was reviewed to identify all patients with histologically confirmed pancreatic ductal adenocarcinoma diagnosed between the years 1985 and 2015. Incidence, mortality, clinicopathological and survival data were analyzed and compared between patients with EOPC and LOPC.Results: From a total of 18 888 patients included in the study, 1324 patients were under the age of 50 years (7.0%). The average annual percentage changes (AAPC) in incidence of all patients with EOPC was -1.0%. The APPC for male patients with EOPC was -2.0% and for female patients was +0.6%. The AAPC in incidence for LOPC was +1.3%. There were no differences in tumor stage, grade or location between EOPC and LOPC. Young patients were more frequently male (64.4% vs. 52.9%), more frequently underwent treatment and had better overall survival. The median survival interval for EOPC was 5.9 months and for LOPC was 4.5 months (p < .001).Conclusions: The clinicopathological features of pancreatic ductal adenocarcinoma were similar in patients under and over the age of 50 years. Patients with EOPC survived longer than patients with LOPC. Continued efforts should be made to diagnose early and treat young patients aggressively.