Synthesis and evaluation biological activity of newly designed hydroxamates as potential HDAC inhibitors

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Title in English Synthesis and evaluation of biological activity of newly designed hydroxamates as potential HDAC inhibitors
Authors

ONUŠČÁKOVÁ Magdaléna PÍŽOVÁ Hana KAUEROVÁ Tereza KOLLÁR Peter BOBÁĽ Pavel

Year of publication 2023
Type Appeared in Conference without Proceedings
MU Faculty or unit

Faculty of Pharmacy

Citation
Description Histone deacetylase inhibitors (HDACi) represent a relatively new generation of drugs with the ability to affect the expression of specific genes, which can repair controlled proliferation or damage apoptotic processes in tumor cells. HDAC inhibitors have considerable anticancer activity forming a complex with the Zn2+ ion in the catalytic pocket of enzymes.2
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