Nekódující RNA v biologii maligních B lymfocytů.

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Title in English Non-coding RNAs in the biology of malignant B lymphocytes.
Authors

FARIA ZENI Pedro FILIP Daniel BOUDNÝ Miroslav MEDKOVÁ Michaela JANSKÁ Libuše MICHAELOU Androniki ONDRIŠOVÁ Laura HOFERKOVÁ Eva VEČEŘA Josef HLAVÁČ Kryštof KOŠŤÁLOVÁ Lenka PAVELKOVÁ Petra BAJUSOVÁ Erika KACZ Péter POSPÍŠILOVÁ Šárka DOUBEK Michael MAYER Jiří ŠEDA Václav MRÁZ Marek

Year of publication 2023
Type Conference abstract
MU Faculty or unit

Central European Institute of Technology

Citation
Attached files
Description B cell receptor (BCR) signaling is essential for both standard and malignant B lymphocytes' maturation, survival, and proliferation. The importance of BCR signaling is highlighted by the high clinical efficacy of inhibitors targeting the BCR-associated BTK and PI3K kinases, especially in chronic lymphocytic leukemia (CLL). Differences in the extent of BCR signaling contribute to variable prognosis in CLL and other “mature” B malignancies, and short non-coding RNAs such as miR-150, miR-155, miR-34a or miR-17-92 play an essential role in this process. However, it remains unclear whether long non-coding RNAs (lncRNAs) are also regulatory BCR signaling and related interactions in the microenvironment. The lecture will focus on the role of non-coding RNAs (ncRNAs) in regulating BCR signaling and other interactions in the microenvironment of malignant B cells, as well as related changes during therapy with targeted drugs. The lecture will include insights into ncRNAs acting as synchronizers of BCR signaling and BT interaction cells.
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